Chem 242 @ Dickinson

Stork and Robinson -- quite a pair!

Today we finished chapter 23 with a look at the Stork Enamine Reaction and the Robinson Annulation Reaction. The Stork is just a glorified Michael Reaction, albeit one that avoids the problem of over-alkylation by eliminating the need for a base. The Robinson is a wonderful Michael/aldol combination that is a chemist's best way to manufacture conjugated cyclohexenes -- this is important in steroid synthesis.

I talked a bit about the exam -- it's heavily mechanistic and a lot like the one from last year. You should be able to handle mechanisms for all of the reactions we've discussed: malonic ester, acetoacetic ester, haloform, aldol, Claisen, Michael, Stork, Robinson, decarboxylation.

Remember that Meagen will be available on Sunday evening from 6 - 8 in the lounge.

posted by DCChem @ 11:10 AM